Cellular Senescence Markers and Matrix Metalloproteinase-7 Are Co-expressed in Fibrosing Interstitial Lung Diseases
Rationale
Cellular senescence is a crucial mechanism implicated in the pathogenesis of pulmonary fibrosis.
MMP-7 is emerging as a significant biomarker for idiopathic pulmonary fibrosis (IPF), its association with cellular senescence in other fibrosing interstitial lung diseases (f-ILDs) remains unknown.
Methods: Cellular senescence markers in lung biopsies
Immunohistochemistry of senescence markers (p16, p21) and MMP-7 was performed on lung biopsies of f-ILD patients (13 IPF and 16 non-IPF f-ILD) and 14 controls.
Quantitative analysis was carried out using QuPath software.
Results: Co-expression of senescence markers and MMP-7
Senescence markers (p16 and p21) were present in both IPF and non-IPF f-ILD patients, but not in controls.
These markers were primarily observed in epithelial cells and showed consistency with MMP-7 distribution.
Senescence markers and MMP-7 were predominantly found in usual interstitial pneumonia (UIP) pattern.
Conclusion: Cellular senescence markers and lung remodeling
There might be an association between MMP-7 and the accelerated aging and senescence process of f-ILD, potentially impacting lung remodeling, particularly in UIP pattern.
Authors
F. Hernandez-Gonzalez, D. Martinez, T. Cruz, N. Mendoza, S. Casas-Recasens, A. Frino-Garcia, N. Perez-Rodas, X. Alsina-Restoy, G. Lopez-Saiz, A.M. Medina, F. Pietrocola, A. Agusti, M. Rojas, M. Serrano, M.R. Faner, J. Sellares Torres
Read more details at
Fecha de publicación
2025 May 19
Categorías asociadas al artículo
Noticias relacionadas
Impact of Ex Vivo Lung Perfusion System on the Lung Microbiome
Discover how ex vivo lung perfusion (EVLP) impacts the lung microbiome and its implications for improving donor lung viability and reducing transplant complications.
Falling through the cracks: what happens to survivors of preterm birth?
Survivors of preterm birth face increased risks of respiratory diseases, yet awareness among specialists is low. This study examines gaps in long-term care, highlighting the need for clear follow-up guidelines and improved communication between medical teams.
The impact of the EVLP on the lung microbiome and its inflammatory reaction
Discover the first study designed to analyze the impact of EVLP on the lung microbiome and the local inflammatory response. Understanding the composition, diversity, and functional interactions of the pulmonary microbiome in lung transplants holds promise for personalized respiratory medicine.
Exploring the Interplay between Cellular Senescence, Immunity, and Fibrosing Interstitial Lung Diseases: Challenges and Opportunities
Discover how cellular senescence, marked by antagonistic pleiotropy, and immune dysregulation play a detrimental role in the pathogenesis of fibrosing interstitial lung diseases (f-ILDs) and pulmonary fibrosis.
Peripheral Immune Cell Profiling Reveals Distinct Immune Hallmarks in Progressive Pulmonary Fibrosis
This study shows that patients with f-ILDs several immune populations in circulating blood, skewed toward an aged and exhausted immune profile, relate to lung function impairment at diagnosis, and that PPF is associated with an increased cytotoxic immune response.
Lung immune signatures define two groups of end-stage IPF patients
To investigate it, we calculated immune signatures with Gene Set Variation Analysis (GSVA) and applied them to the lung transcriptome followed by unbiased cluster analysis of GSVA immune-enrichment scores, in 109 IPF patients from the Lung Tissue Research Consortium (LTRC)
Imagen desarrollada IA, retoque gráfico y Canva