Phenotypic differences of persistent airflow obstruction in young vs old subjects in the general population
Background: Persistent airflow obstruction in young and older individuals
In the article titled «Phenotypic differences of persistent airflow obstruction in young vs old subjects in the general population», the focus is on comparing the phenotypic differences of Persistent Airflow Obstruction (PAO) in young (<50 yrs) and older (>70 yrs) subjects.
Method: Young and elderly individuals with PAO comparison
Young and old subjects with PAO were contrasted in the LEAD cohort, a single-centered, observational, population-based study in Vienna (Austria).
Results
Young subjects with PAO were more frequently current smokers, had a higher diffusion capacity, a more prevalent diagnosis of asthma, lower levels of circulating inflammatory markers and less dyspnea than old PAO.
When stratified by their cumulative smoking exposure, we observed that old PAO with ≥10PY (Pack Years) had significantly reduced FEV1 vs <10PY, and that young and old PAOs with ≥10PY had lower DLCO, reduced asthma prevalence, more symptoms and more inflammatory markers than respective <10PY.
Conclusions: Significant phenotypic differences between young and old individuals with Persistent airflow obstruction
The conclusion underscores that while PAO in the general population is largely mild, there are significant phenotypic differences between young and old individuals with PAO. A significant fraction of young PAO did not have substantial smoking history. In contrast, young PAO with ≥10PY are more similar to old PAO
Authors
Caspar Schiffers, Rosa Faner, Marie-Kathrin Breyer, Sylvia Hartl, Robab Breyer-Kohansal, Alvar Agusti.
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