Pulmonary vascular reactivity in growth restricted fetuses using computational modelling and machine learning analysis of fetal Doppler waveforms
Abstract
The aim of this study was to investigate the pulmonary vasculature in baseline conditions and after maternal hyperoxygenation in growth restricted fetuses (FGR)
A prospective cohort study of singleton pregnancies including 97 FGR and 111 normally grown fetuses was carried out. Ultrasound Doppler of the pulmonary vessels was obtained at 24-37 weeks of gestation and data were acquired before and after oxygen administration. After, Machine Learning (ML) and a computational model were used on the Doppler waveforms to classify individuals and estimate pulmonary vascular resistance (PVR). Our results showed lower mean velocity time integral (VTI) in the main pulmonary and intrapulmonary arteries in baseline conditions in FGR individuals. Delta changes of the main pulmonary artery VTI and intrapulmonary artery pulsatility index before and after hyperoxygenation were significantly greater in FGR when compared with controls. Also, ML identified two clusters: A (including 66% controls and 34% FGR) with similar Doppler traces over time and B (including 33% controls and 67% FGR) with changes after hyperoxygenation. The computational model estimated the ratio of PVR before and after maternal hyperoxygenation which was closer to 1 in cluster A (cluster A 0.98 ± 0.33 vs cluster B 0.78 ± 0.28, p = 0.0156). Doppler ultrasound allows the detection of significant changes in pulmonary vasculature in most FGR at baseline, and distinct responses to hyperoxygenation. Future studies are warranted to assess its potential applicability in the clinical management of FGR.
Authors
Kilian Vellvé, Patricia Garcia-Canadilla, Mariana Nogueira, Lina Youssef, Angela Arranz, Ayako Nakaki, David Boada 1, Isabel Blanco, Rosa Faner, Francesc Figueras, Àlvar Agustí, Eduard Gratacós, Francesca Crovetto, Bart Bijnens, Fàtima Crispi.
Read more
Noticias relacionadas
General population-based lung function trajectories over the life course: an accelerated cohort study
Empirical life course lung function trajectories from ages 4–80 using data from eight cohort studies in Europe and Australia.
Residential greenspace and lung function throughout childhood and adolescence in five European birth cohorts. A CADSET initiative
Study of five European cohorts found no association between residential greenness or urban green space and lung function throughout childhood and adolescence.
Alteraciones espirométricas y sus factores de riesgo en la población joven ambulatoria
Un estudio reciente en Osona (Cataluña) refleja que 20,7% de jóvenes presenta alteraciones espirométricas. También revela síntomas y factores de riesgo en la población joven ambulatoria.
Artículos
Estudios
- 759397·Alberto Sandiumenge et Al.-Systemic Inflammation Differences in Brain-vs. Circulatory-Dead Donors: Impact on Lung Transplant Recipients
- 759578·Alberto Papi et Al.-Relationships between symptoms and lung function in asthma and/or chronic obstructive pulmonary disease in a real-life setting: the NOVEL observational longiTudinal studY
- 759689·Kilian Vellvé et Alt.- Pulmonary vascular reactivity in growth restricted fetuses using computational modelling and machine learning analysis of fetal Doppler waveforms.
- 769273· Singh D, Criner GJ, Agustí A et al. Benralizumab Prevents Recurrent Exacerbations in Patients with Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis
- 769685·Nuria Olvera et Al.- Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
Imagen creada con imágenes libres de Canva Pro e infografía de la noticia original.