Treatable trait guided asthma management: biomarker changes and responder analysis
Aim: In a feasibility study, treatable trait (TT) guided asthma management showed clinically relevant improvements in asthma control (ACQ), quality of life (AQLQ), health status (SGRQ) and FEV1 (Fingleton et al, TSANZ ASM 2023). Changes in two type-2 (T2) biomarkers, blood eosinophils and FeNO, and associations between baseline characteristics and treatment response are described here.
Methods: Ten week two-centre open-label intervention study of patients with asthma receiving medication titrated to presence of two TTs: T2 inflammation and airflow obstruction. Participants had ACQ >1 and ≥1 exacerbation in last 12 months. Linear regression estimates changes in continuous response variables in relation to predictors.
Results: Airflow obstruction was present in 18/30 (60%) participants. Although TT intervention was associated with reduction of type-2 inflammation (Figure); change in ACQ, AQLQ, or SGRQ was not associated with baseline FEV1/FVC, log FeNO, blood eosinophils or composite T2 biomarker status. Final FEV1% predicted, adjusted for baseline, was associated with baseline airflow obstruction. Change in FEV1 predicted per unit increase FEV1/FVC ratio (95% CI), -1.69% (-2.26 to -1.13), P<0.001.
Puedes leer el artículo completo aquí: https://erj.ersjournals.com/content/62/suppl_67/PA3604
Authors: James Fingleton, Rob Mclachlan, Jenny Sparks, Richard Beasley, Alvar Agusti, Peter G Gibson, Ian Pavord, Jo Hardy, Mark Weatherall, Allie Eathorne, Vanessa M Mcdonald
European Respiratory Journal 2023 62: PA3604; DOI: 10.1183/13993003.congress-2023.PA3604
Noticias relacionadas
Climate Change & COPD: A GOLD Science Committee Review
Climate change and COPD are linked through extreme temperature, wildfire smoke, dust storms and allergen exposure, which pose major health threats.
Occluding mucous airway plugs in patients with obstructive lung diseases: a new treatable trait?
Airway mucous plugging is associated with exacerbations, lung function decline, and mortality in COPD, asthma, and bronchiectasis. Identifying it as a treatable trait may improve patient outcomes through airway clearance techniques and pharmacological strategies.
Trajectories of airflow limitation from childhood to early adulthood: an analysis of six population-based birth cohorts
Airflow limitation can worsen or improve from school age to adulthood at all severity levels. This study examines lung function changes and the impact of BMI and wheezing, highlighting key health interventions.
Artículos
Asthma
- 759578·Alberto Papi et Al.-Relationships between symptoms and lung function in asthma and/or chronic obstructive pulmonary disease in a real-life setting: the NOVEL observational longiTudinal studY
- 759785·Richard Beasley et Al – Prevalence, Diagnostic Utility and Associated Characteristics of Bronchodilator Responsiveness
- 768973·James Fingleton, Rob Mclachlan, Jenny Sparks, Richard Beasley, Alvar Agusti, Peter G Gibson, Ian Pavord, Jo Hardy, Mark Weatherall, Allie Eathorne, Vanessa Mcdonal -Treatable trait guided asthma management: biomarker changes and responder analysis
- 768973·Xander Bertels et Al.- Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET Clinical Research Collaboration
- 769799·Alvar Agusti, Peter G. Gibson, Vanessa M. McDonald. Treatable Traits in Airway Disease: From Theory to Practice
Recuerda que puedes acceder a varios enlaces a artículos dentro de la categoría GOLD en esta web. También puedes acceder otros enlaces en el Listado de Artículos de la Cátedra de Salud Respiratoria.
Imagen obtenida en artículo original.