Treatment Trials in Young Patients with Chronic Obstructive Pulmonary Disease and Pre-Chronic Obstructive Pulmonary Disease Patients: Time to Move Forward

Chronic obstructive pulmonary disease (COPD) is the end result of a series of dynamic and cumulative gene-environment interactions over a lifetime. The evolving understanding of COPD biology provides novel opportunities for prevention, early diagnosis, and intervention. To advance these concepts, we propose therapeutic trials in two major groups of subjects: «young» individuals with COPD and those with pre-COPD.

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Autores: Fernando J Martinez, Alvar Agusti, Bartolome R Celli, MeiLan K Han, James P Allinson, Surya P Bhatt, Peter Calverley, Sanjay H Chotirmall, Badrul Chowdhury, Patrick Darken, Carla A Da Silva, Gavin Donaldson, Paul Dorinsky, Mark Dransfield, Rosa Faner, David M Halpin, Paul Jones, Jerry A Krishnan, Nicholas Locantore, Fernando D Martinez, Hana Mullerova, David Price, Klaus F Rabe, Colin Reisner, Dave Singh, Jørgen Vestbo, Claus F Vogelmeier, Robert A Wise, Ruth Tal-Singer, Jadwiga A Wedzicha.