Association of Preserved Ratio Impaired Spirometry (PRISm) with Arterial Stiffness
PRISm: A Link to Increased Cardiovascular Morbidity and Mortality
Preserved ratio impaired spirometry (PRISm) is a recently recognized spirometric pattern defined by forced expiratory volume in 1 second (FEV1) / Forced vital capacity ratio ≥0.70 and FEV1 <80% of reference. For unclear reasons, PRISm is associated with increased cardiovascular (CV) morbidity and mortality. Arterial stiffness is a major mechanism of CV disease, which can be measured by carotid-femoral pulse wave velocity (cfPWV).
Objectives
We explored the hypothesis that cfPWV would be increased in individuals with PRISm and airflow limitation (AL).
Methods
We measured forced spirometry, lung volumes by body plethysmography, and cfPWV in 9,466 subjects recruited from the general population in the Austrian cross-sectional LEAD study, and tested the association of arterial stiffness with PRISm and AL by multivariable linear regression analysis. Individuals aged 18 years and under as well as those with missing cfPWV or co-variates were excluded from further analysis.
Results
Individuals with PRISm (4.6%) were of similar age to those with normal spirometry (85.9%) and significantly younger than those with AL (9.5%).
Arterial hypertension, diabetes mellitus, coronary artery disease, heart failure and peripheral arterial occlusive disease were significantly more common in individuals with PRISm compared to normal lung function and similar to those with AL.
There was a significant association between PRISm and arterial stiffness on bivariate linear regression analysis ,which persisted after robust adjustment for clinical confounders upon multivariable analysis.
CfPWV was significantly higher in individuals with PRISm irrespective of the presence of established CV disease or pulmonary restriction.
AL also showed a significant association with arterial stiffness on multivariable linear regression analysis.
Conclusions
Arterial stiffness measured by cfPWV is increased in individuals with PRISm independent from CV disease and risk factors. The pathobiological mechanisms underlying this association deserve further research.
Authors
Christoph C. Kaufmann , Marie-Kathrin Breyer ; Sylvia Hartl ; Christoph Gross , Caspar Schiffers ; Emiel F.M. Wouters ; Robab Breyer-Kohansal ; Thomas Weber , Kurt Huber ; Alvar Agusti , and Otto C. Burghuber ;
Read more details at
Noticias relacionadas
Trajectories of airflow limitation from childhood to early adulthood: an analysis of six population-based birth cohorts
Airflow limitation can worsen or improve from school age to adulthood at all severity levels. This study examines lung function changes and the impact of BMI and wheezing, highlighting key health interventions.
Entrevista SEMG al Dr. Alvar Agusti, Experto en la II Jornada Resprimaria
Descubre los avances en el diagnóstico y tratamiento de la EPOC con el Dr. Alvar Agustí en la II Jornada SEMG Resprimaria. Conoce la importancia de la espirometría, la detección precoz y las nuevas estrategias terapéuticas.
Falling through the cracks: what happens to survivors of preterm birth?
Survivors of preterm birth face increased risks of respiratory diseases, yet awareness among specialists is low. This study examines gaps in long-term care, highlighting the need for clear follow-up guidelines and improved communication between medical teams.
Artículos
Spirometry-Espirometría
- 759578·Alberto Papi et Al.-Relationships between symptoms and lung function in asthma and/or chronic obstructive pulmonary disease in a real-life setting: the NOVEL observational longiTudinal studY
- 768973·Xander Bertels et Al.- Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET Clinical Research Collaboration
Imagen obtenida en Canva Pro.
