Early-stage lung immune infiltrate in idiopathic pulmonary fibrosis and its association with stable versus progressive disease in early IPF patients.
Study highlights the role of cellular senescence markers (p16, p21) and MMP-7 co-expression in fibrosing interstitial lung diseases.
Research on idiopathic pulmonary fibrosis reveals how immune infiltrate differences in early stages influence disease progression. Study highlights the role of B cells, T cells, and NK cells as potential biomarkers.
Discover how cellular senescence, marked by antagonistic pleiotropy, and immune dysregulation play a detrimental role in the pathogenesis of fibrosing interstitial lung diseases (f-ILDs) and pulmonary fibrosis.
To investigate it, we calculated immune signatures with Gene Set Variation Analysis (GSVA) and applied them to the lung transcriptome followed by unbiased cluster analysis of GSVA immune-enrichment scores, in 109 IPF patients from the Lung Tissue Research Consortium (LTRC)
