Lung-function trajectories: relevance and implementation in clinical practice
Lung development starts in utero and continues during childhood through to adolescence, reaching its peak in early adulthood. This growth is followed by gradual decline due to physiological lung ageing.
Lung-function development can be altered by several host and environmental factors during the life course. As a result, a range of lung-function trajectories exist in the population.
Below average trajectories are associated with respiratory, cardiovascular, metabolic, and mental health comorbidities, as well as with premature death.
This Review presents progressive research into lung-function trajectories and assists the implementation of this knowledge in clinical practice as an innovative approach to detect poor lung health early, monitor respiratory disease progression, and promote lung health.
Specifically, we propose that, similar to paediatric height and weight charts used globally to monitor children’s growth, lung-function charts could be used for both children and adults to monitor lung health status across the life course.
To achieve this proposal, we introduce our free online Lung Function Tracker tool. Finally, we discuss challenges and opportunities for effective implementation of the trajectory concept at population level and outline an agenda for crucial research needed to support such implementation.
Puedes leer el artículo completo aquí: https://www.sciencedirect.com/science/article/pii/S0140673624000163
Autores: Prof Erik Melén, Prof Rosa Faner, James P Allinson, Dinh Bui, Prof Andrew Bush, Prof Adnan Custovic, Prof Judith Garcia-Aymerich, Prof Stefano Guerra, Robab Breyer-Kohansal, Jenny Hallberg, Prof Lies Lahousse, Prof Fernando D Martinez, Simon Kebede Merid, Pippa Powell, Prof Hilary Pinnock, Sanja Stanojevic, Lowie E G W Vanfleteren, Gang Wang, Prof Shyamali C Dharmage, Prof Jadwiga Wedzicha, Nazanin Zounemat Kermani.
Noticias relacionadas
Monitoring and assessment of CO2 and NO2 in schools within the Sentinel Schools Network of Catalonia during the COVID-19 era
Explore how the COVID-19 Sentinel Schools Network of Catalonia monitored CO2 and NO2 levels in classrooms, revealing key findings on ventilation and air quality in schools across Catalonia during the pandemic.
Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study
A study that identifies four lung function trajectories in children, highlighting that physical activity and BMI at 4 years predict catch-up lung function growth, particularly zFEV1, but not zFVC.
Coffee Talk: CADSET-explaining the lung function tracker tool
The latest episode of Coffee Talk sees co-chairs of the ERS Clinical Research Collaboration CADSET, Prof. Erik Melén and Prof. Rosa Faner, catch up to discuss the topic of the new lung function tracker tool.
Relationship between Respiratory Microbiome and Systemic Inflammatory Markers in COPD: A Pilot Study
This study explores how changes in the respiratory microbiome relate to systemic inflammation in COPD patients. It highlights correlations between bacterial abundance, eosinophilic markers, and airflow limitation severity.
Change is in the air: key questions on the ‘Treatable Traits’ model for chronic airway diseases in primary care
Explore Treatable Traits model for chronic airway diseases like asthma and COPD in primary care. Learn about seven key traits — airflow obstruction, eosinophilic inflammation, adherence, inhaler technique, smoking, low BMI/obesity and anxiety and depression — that guide personalized care.
Telomere length in patients with bronchiectasis
This study investigates telomere length (TL) in bronchiectasis patients, comparing them to COPD patients and healthy controls. Findings show no significant TL reduction in bronchiectasis compared to controls, but a trend towards shorter TL in idiopathic cases. Further research is needed to understand TL’s role in bronchiectasis.
Artículos
Función pulmonar
- 759689·Kilian Vellvé et Alt.- Pulmonary vascular reactivity in growth restricted fetuses using computational modelling and machine learning analysis of fetal Doppler waveforms.
- 759771·Sandra Casas-Recasens; Raisa Cassim, Nuria Mendoza; Alvar Agusti; Caroline Lodge; Shuai Li; Dinh Bui; David Martino; Shyamali C. Dharmage, and Rosa Faner.-Epigenome-Wide Association Studies of COPD and Lung Function: A Systematic Review
- 769289·Caspar Schiffers, Rosa Faner, et al. Supranormal lung function: Prevalence, associated factors and clinical manifestations across the lifespan.
- 769491·Tamara Cruz, Núria Mendoza, Gema M Lledó, Lídia Perea, Núria Albacar, Alvar Agustí, Jacobo Sellares, Oriol Sibila, Rosa Faner. Persistence of a SARS-CoV-2 T-cell response in patients with long COVID and lung sequelae after COVID-19
- 769685·Nuria Olvera et Al.- Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
Imagen creada con imágenes libres de Canva Pro.
