Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET Clinical Research Collaboration
Background "Phenotyping asthma with airflow obstruction in middle-aged and older adults"
Asthma with fixed airflow obstruction (AFO) is associated with higher exacerbation rates and mortality compared to non-obstructed asthma, yet its prevalence and clinical profile remain uncertain.
Objetives
We aimed to determine the prevalence, characteristics, and comorbidities of asthma with airflow obstruction in adults ≥50 years.
Methods
Participants with spirometry data from 9 CADSET cohorts (n=69,789) were cross-sectionally analyzed. In 2 asthma- and 4 COPD cohorts, AFO was defined as ever diagnosed asthma with post-BD FEV1/FVC<0.7. In 3 population cohorts, AFO was defined as ever asthma with pre-BD FEV1/FVC<0.7. The prevalence and co-morbidities of AFO were meta-analyzed and characteristics were compared to asthma without airflow obstruction (asthma-only) and COPD without asthma history (COPD-only).
Results
The prevalence of AFO was 2.2% (95%CI: 1.8-2.6%) in the general population, 21.0% (18.5-23.8%) in asthma cohorts and 9.9% (5.0-18.7%) in COPD cohorts. AFO patients reported significantly more dyspnea than asthma- and COPD-only. Compared to asthma-only, AFO were older, more often male, current smokers, had lower BMI, and had higher white blood cell counts, yet showed no significant difference in co-morbidities. Compared to COPD-only, AFO were younger, more often female, never smokers, had higher BMI and had more often depression (24.5 vs 11.5%, p=0.01), osteoporosis (21.8 vs 13.4%, p<0.01), and gastro-esophageal reflux disease (GERD; 36.6 vs 24.7%, p<0.01).
Conclusion
AFO is a prevalent respiratory phenotype associated with more dyspnea than asthma- and COPD-only. AFO patients had more depression, osteoporosis, and GERD compared to COPD-only.
Authors
Xander Bertels, Ahmed Edris, Judith Garcia-Aymerich, Rosa Faner, Howraman Meteran, Torben Sigsgaard, Peter Alter, Claus Vogelmeier, Núria Olvera, Nazanin Zounemat-Kermani, Alvar Agusti, Gavin Donaldson, Jadwiga Wedzicha, Guy Brusselle, Helena Backman, Eva Rönmark, Anne Lindberg, Judith Vonk, Kian Fan Chung, Ian Adcock, Maarten Van Den Berge, Lies Lahousse
Read more
Noticias relacionadas
Falling through the cracks: what happens to survivors of preterm birth?
Survivors of preterm birth face increased risks of respiratory diseases, yet awareness among specialists is low. This study examines gaps in long-term care, highlighting the need for clear follow-up guidelines and improved communication between medical teams.
Fractional exhaled nitric oxide in a respiratory healthy general population through the lifespan
Discover the normal ranges of fractional exhaled nitric oxide (FeNO) across different age groups in a respiratory healthy population. Based on 2,251 participants, this study identifies factors like age, body height, and eosinophil counts that influence FeNO levels.
Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis
Explore the causes of reduced FEV1 in early adulthood, with data from Lifelines and BAMSE cohorts. Findings highlight PRISm and airflow limitation origins, early identification in childhood, and differentiated clinical implications.
Falling through the cracks: what happens to survivors of preterm birth?
Survivors of preterm birth face increased risks of respiratory diseases, yet awareness among specialists is low. This study examines gaps in long-term care, highlighting the need for clear follow-up guidelines and improved communication between medical teams.
Artificial Intelligence in COPD
Artificial Intelligence in COPD is transforming disease management, from underdiagnosis to treatment guidance. Discover how machine learning clusters patients, predicts outcomes, and optimizes healthcare resources.
Heterogeneity of reduced FEV1 in early adulthood: A looking forward, looking backwards analysis
Explore the causes of reduced FEV1 in early adulthood, with data from Lifelines and BAMSE cohorts. Findings highlight PRISm and airflow limitation origins, early identification in childhood, and differentiated clinical implications.
Artículos
Asthma
- 759578·Alberto Papi et Al.-Relationships between symptoms and lung function in asthma and/or chronic obstructive pulmonary disease in a real-life setting: the NOVEL observational longiTudinal studY
- 759785·Richard Beasley et Al – Prevalence, Diagnostic Utility and Associated Characteristics of Bronchodilator Responsiveness
- 768973·James Fingleton, Rob Mclachlan, Jenny Sparks, Richard Beasley, Alvar Agusti, Peter G Gibson, Ian Pavord, Jo Hardy, Mark Weatherall, Allie Eathorne, Vanessa Mcdonal -Treatable trait guided asthma management: biomarker changes and responder analysis
- 768973·Xander Bertels et Al.- Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET Clinical Research Collaboration
- 769799·Alvar Agusti, Peter G. Gibson, Vanessa M. McDonald. Treatable Traits in Airway Disease: From Theory to Practice
Estudios
- 759397·Alberto Sandiumenge et Al.-Systemic Inflammation Differences in Brain-vs. Circulatory-Dead Donors: Impact on Lung Transplant Recipients
- 759578·Alberto Papi et Al.-Relationships between symptoms and lung function in asthma and/or chronic obstructive pulmonary disease in a real-life setting: the NOVEL observational longiTudinal studY
- 759689·Kilian Vellvé et Alt.- Pulmonary vascular reactivity in growth restricted fetuses using computational modelling and machine learning analysis of fetal Doppler waveforms.
- 769273· Singh D, Criner GJ, Agustí A et al. Benralizumab Prevents Recurrent Exacerbations in Patients with Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis
- 769685·Nuria Olvera et Al.- Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
Imagen obtenida en Canva Pro.
