Pulmonary vascular reactivity in growth restricted fetuses using computational modelling and machine learning analysis of fetal Doppler waveforms
![](https://catedrasaludrespiratoria.com/wp-content/uploads/2024/03/FGR.jpg)
Abstract
The aim of this study was to investigate the pulmonary vasculature in baseline conditions and after maternal hyperoxygenation in growth restricted fetuses (FGR)
A prospective cohort study of singleton pregnancies including 97 FGR and 111 normally grown fetuses was carried out. Ultrasound Doppler of the pulmonary vessels was obtained at 24-37 weeks of gestation and data were acquired before and after oxygen administration. After, Machine Learning (ML) and a computational model were used on the Doppler waveforms to classify individuals and estimate pulmonary vascular resistance (PVR). Our results showed lower mean velocity time integral (VTI) in the main pulmonary and intrapulmonary arteries in baseline conditions in FGR individuals. Delta changes of the main pulmonary artery VTI and intrapulmonary artery pulsatility index before and after hyperoxygenation were significantly greater in FGR when compared with controls. Also, ML identified two clusters: A (including 66% controls and 34% FGR) with similar Doppler traces over time and B (including 33% controls and 67% FGR) with changes after hyperoxygenation. The computational model estimated the ratio of PVR before and after maternal hyperoxygenation which was closer to 1 in cluster A (cluster A 0.98 ± 0.33 vs cluster B 0.78 ± 0.28, p = 0.0156). Doppler ultrasound allows the detection of significant changes in pulmonary vasculature in most FGR at baseline, and distinct responses to hyperoxygenation. Future studies are warranted to assess its potential applicability in the clinical management of FGR.
Authors
Kilian Vellvé, Patricia Garcia-Canadilla, Mariana Nogueira, Lina Youssef, Angela Arranz, Ayako Nakaki, David Boada 1, Isabel Blanco, Rosa Faner, Francesc Figueras, Àlvar Agustí, Eduard Gratacós, Francesca Crovetto, Bart Bijnens, Fàtima Crispi.
Read more
Noticias relacionadas
![Polygenic Risk Score for COPD](https://catedrasaludrespiratoria.com/wp-content/uploads/2024/07/Polygenic-Risk-Score-for-COPD-opt-300x225.webp)
Association of a polygenic risk score for chronic obstructive pulmonary disease with lung function across the lifespan
Discover the strong associations between a polygenic risk score for COPD and lung function from childhood to elderly. Study includes individuals aged 4-84 years, revealing significant links from school age to elderly.
![Bayesian modelling of FEV1 and FVC trajectories](https://catedrasaludrespiratoria.com/wp-content/uploads/2024/07/Bayesian-modelling-of-FEV1-and-FVC-trajectories-300x225.webp)
Bayesian modelling of combined FEV1 and FVC vital lung function trajectories: relationship with airflow obstruction and PRISm
Discover how Bayesian non-parametric trajectory modeling identified seven combined FEV1 and FVC life-course trajectories and their association with airflow obstruction (AO) and PRISm. Learn about the prevalence and onset age across trajectories based on the Framingham Offspring Cohort study.
![DNA Methylation in COPD](https://catedrasaludrespiratoria.com/wp-content/uploads/2024/07/dna-methylation-in-copd-v2-300x225.webp)
Is the association between the severity of airflow limitation and DNA Methylation similar in blood and lung tissue in patients with COPD?
The relationship between airflow limitation severity and DNA methylation in COPD patients. Findings reveal CpGs with opposite associations in blood and lung tissues, highlighting distinct regulatory mechanisms.
Artículos
Estudios
- 759397·Alberto Sandiumenge et Al.-Systemic Inflammation Differences in Brain-vs. Circulatory-Dead Donors: Impact on Lung Transplant Recipients
- 759578·Alberto Papi et Al.-Relationships between symptoms and lung function in asthma and/or chronic obstructive pulmonary disease in a real-life setting: the NOVEL observational longiTudinal studY
- 759689·Kilian Vellvé et Alt.- Pulmonary vascular reactivity in growth restricted fetuses using computational modelling and machine learning analysis of fetal Doppler waveforms.
- 769273· Singh D, Criner GJ, Agustí A et al. Benralizumab Prevents Recurrent Exacerbations in Patients with Chronic Obstructive Pulmonary Disease: A Post Hoc Analysis
- 769685·Nuria Olvera et Al.- Lung Tissue Multi-Layer Network Analysis Uncovers the Molecular Heterogeneity of COPD
Imagen creada con imágenes libres de Canva Pro e infografía de la noticia original.