Relationships between symptoms and lung function in asthma and/or chronic obstructive pulmonary disease in a real-life setting: the NOVEL observational longiTudinal studY

Symptoms and Lung Function in Astma and COPD

Background: Asthma and COPD share many symptoms

Asthma and chronic obstructive pulmonary disease (COPD) have many symptoms in common.

To confirm diagnosis, doctors use spirometry, a test to measure the amount of air that can be breathed out from the lungs and how fast it can be blown out.

The relationship between these measurements and symptoms in asthma and COPD is not well understood.


The aim of this research is to describe the characteristics, treatment, and impact of asthma and/or COPD in patients who are receiving their usual medical care.


NOVELTY is a large study of around 12,000 patients across 19 countries. This analysis of NOVELTY looked at the relationships between two spirometry measurements and the symptoms of asthma and/or COPD experienced by patients. The spirometry measurements were:

  • Forced Expiratory Volume in 1 Second (FEV1) – The amount of air that can be blown out of the lungs in 1 second.
  • Forced Vital Capacity (FVC) – The amount of air that can be forcibly breathed out from the lungs after taking the deepest breath possible.


The lower the FEV1 and FVC, the more common the symptoms of breathlessness, wheeze attacks, night-time awakening, and coughing up of phlegm or mucus.

These relationships were similar for FEV1 and FVC. Lower FEV1 was more strongly associated with worse symptoms in COPD than in asthma.


These findings help to improve our understanding of the relationships between spirometry measures and symptoms in patients with asthma and/or COPD.


Alberto Papi, Rod Hughes, Ricardo del Olmo, Alvar Agusti, Bradley E. Chipps, Barry Make, Erin Tomaszewski, Keith Peres Da Costa, Divyansh Srivastava, Jørgen Vestbo, Christer Janson, Pierre-Régis Burgel and David Price

Read more details at

Noticias relacionadas


Imagen desarrollada desde DALL-E y editada en Canva

Entérate de
Nuestras Publicaciones