Study highlights the role of cellular senescence markers (p16, p21) and MMP-7 co-expression in fibrosing interstitial lung diseases.
Discover how cellular senescence, marked by antagonistic pleiotropy, and immune dysregulation play a detrimental role in the pathogenesis of fibrosing interstitial lung diseases (f-ILDs) and pulmonary fibrosis.
Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases.
Most patients with chronic obstructive pulmonary disease (COPD) have at least one additional, clinically relevant chronic disease. Those with the most severe airflow obstruction will die from respiratory failure, but most patients with COPD die from non-respiratory disorders, particularly cardiovascular diseases and cancer.
