Body Mass Index-related genetic factors and COPD imaging phenotypes
BMI genetic factors and COPD imaging phenotypes
Rationale
While low body mass index (BMI) is associated with emphysema and obesity is associated with airway disease in chronic obstructive pulmonary disease (COPD), the underlying mechanisms are unclear.
Objectives
To examine the association between BMI-related genetic variants and emphysema and airway disease imaging phenotypes.
Methods and imaging phenotypes
We examined associations of the PGSBMI with automated quantification and visual interpretation of computed tomographic emphysema and airway wall thickness (AWT) in COPD-enriched and community-based cohorts.
BMI polygenic risk, emphysema and airway wall thickness
For imaging characteristics assessed by visual interpretation, a higher PGSBMI was associated with reduced emphysema in both COPD-enriched cohorts (odds ratio [OR] for a higher severity grade = 0.89, P = .0080) and in the community-based Framingham Heart Study (OR for the presence of emphysema = 0.82, P = .0034), and a higher risk of airway wall thickening in the COPDGene study (OR = 1.17, P = .0023).
Conclusions
In individuals with and without COPD, a higher BMI polygenic risk is associated with both quantitative and visual decreased emphysema and increased AWT, suggesting genetic determinants of BMI affect both emphysema and airway wall thickening.
Authors
Jingzhou Zhang, Matthew Moll, Catherine L Debban, Brian D Hobbs, Heena Rijhwani, George R Washko, Bartolome R Celli, Edwin K Silverman, Per Bakke, Elizabeth C Oelsner, R Graham Barr, Alvar Agustí, Rosa Faner, Guy G Bruselle, Stephen M Humphries, David A Lynch, Josée Dupuis, Ani W Manichaikul, George T O’Connor, Michael H Cho
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Fecha de publicación
21 February 2026.
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