Marked differences in peripheral blood immune cell gene expression were observed between bronchiectasis patients and healthy controls.
Transcriptomic changes were associated with disease severity and airway inflammation identifying potential novel biomarkers and therapeutic targets.
Some patients develop post-COVID organizing pneumonia (OP), which is responsiveto treatment with corticosteroids.
The efficacy and safety of mepolizumab in patients with COPD has been investigated in two placebo-controlled Phase 3 trials, METREX and METREO, and theongoing MATINEE trial.
Treatment with LABA/LAMA is recommended in GOLD B patients. We hypothesized that triple therapy (LABA/LAMA/ICS) will be superior to LABA/LAMA in achieving and maintaining clinical control
COPD in the 21st Century: Alvar Agustì and Rosa Faner are part of this book, being authors of chapter 4. Scientists and clinicians across many countries have made great efforts to understand this important disease, and these have yielded positive results.
Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition. We hypothesized that the unbiased integration of different COPD lung omics using a novel multi-layer approach may unravel mechanisms associated with clinical characteristics.
Insight into the impact of doxycycline in therapeutic trials for COPD, emphasizing the need for careful microbiological monitoring in future interventional trials in patients with COPD
In the general population Persistent Airflow Obstruction (PAO) was largely mild but there are significant phenotypic differences between young and old individuals with PAO
Uncover the prevalence, characteristics, and comorbidities of asthma with airflow obstruction (AFO) in adults over 50. Learn how AFO compares to asthma-only and COPD-only in this comprehensive study.
Some patients with COPD suffer frequent exacerbations (FE). We hypothesised that their systemic proteomic profile would be different from that of non-frequent exacerbators (NFE).
