Physical activity and body mass related to catch-up lung function growth in childhood: a population-based accelerated cohort study
Objective: Identifying Predictors of Catch-Up Lung Function Growth in Childhood
The existence of catch-up lung function growth and its predictors is uncertain. We aimed to identify lung function trajectories and their predictors in a population-based birth cohort.
Methods: Assessing Lung Function Trajectories in a Population-Based Cohort Study
We applied group-based trajectory modelling to z-scores of forced expiratory volume in 1 second (zFEV1) and z-scores of forced vital capacity (zFVC) from 1151 children assessed at around 4, 7, 9, 10, 11, 14 and 18 years.
Multinomial logistic regression models were used to test whether potential prenatal and postnatal predictors were associated with lung function trajectories.
Results: Physical Activity and BMI at Age 4 Linked to Catch-Up Lung Function Growth
We identified four lung function trajectories: a low (19% and 19% of the sample for zFEV1 and zFVC, respectively), normal (62% and 63%), and high trajectory (16% and 13%) running in parallel, and a catch-up trajectory (2% and 5%) with catch-up occurring between 4 and 10 years.
Fewer child allergic diseases and higher body mass index z-score (zBMI) at 4 years were associated with the high and normal compared with the low trajectories, both for zFEV1 and zFVC.
Increased children’s physical activity during early childhood and higher zBMI at 4 years were associated with the catch-up compared with the low zFEV1 trajectory (relative risk ratios: 1.59 per physical activity category (1.03–2.46) and 1.47 per zBMI (0.97–2.23), respectively). No predictors were identified for zFVC catch-up growth.
Conclusion: Catch-Up Lung Function Growth Influenced by Early Physical Activity and BMI
We found three parallel-running and one catch-up zFEV1 and zFVC trajectories, and identified physical activity and body mass at 4 years as predictors of zFEV1 but not zFVC catch-up growth.
Authors
Sarah Koch, Gabriela Prado Peralta, Anne-Elie Carsin, Alicia Abellan, Celine Roda, Maties Torrent, Carmen Iñiguez, Ferran Ballester, Amparo Ferrero, Carlos Zabaleta, Aitana Lertxundi, Mònica Guxens, Martine Vrijheid, Jordi Sunyer, Maribel Casas, Judith Garcia-Aymerich
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