Advances in Pipeline of new COPD Treatments

Pipeline of New COPD Treatments
Discover the latest advances now pipeline new COPD treatments pipeline, from monoclonal antibodies to emerging therapies, and future opportunities in clinical development.

Treatment of chronic obstructive pulmonary disease: current pipeline and new opportunities

Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder of the lungs that affects about 10% of the adult population and is currently the third leading global cause of death. 

COPD is the result of multiple, repeated and dynamic gene–environment interactions, starting early in life, that determine the lung function trajectory that a given individual follows over a lifetime.

Therapeutic Opportunities in New COPD Treatments

Increasing understanding of COPD pathogenesis has opened many new opportunities for drug development, including recently approved monoclonal antibodies that reduce inflammatory cytokine signalling by targeting the IL-4α receptor or the eosinophil-activating IL-5.

Drugs Under Clinical Development

Drugs targeting a range of other culprits involved in COPD, including neutrophils, alarmins and kinases, are also in clinical development.

Future Directions in COPD Trials with New COPD Treatments

As the current pipeline of drugs in development for COPD matures, potential areas for novel therapies continue to emerge while lessons from ongoing trials such as patient stratification can be used to refine the design of future trials in this disease.

Authors

Alvar Agusti, Dave Singh, Rosa Faner

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Fecha de publicación

Published: 22 September 2025

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