Treatable Trait Guided Asthma Management: A Feasibility Study
Treatable Trait-Based Asthma Management as a Pathway to Precision Medicine
Treatable traits are patient characteristics that can be identified by clinical, physiological, or biological markers, or other investigations; are treatment responsive, and have clinical relevance. They represent a pathway to precision medicine.
Clinical Benefits of Treatable Trait-Based Asthma Management in Severe Asthma Clinics
This approach is widely used internationally in tertiary hospital severe asthma clinics, although usually called systematic or multidimensional assessment, and is associated with improvements in asthma control, better quality of life, and reduced severe exacerbations
The Need for Evidence in Treatable Trait-Based Asthma Management Beyond Tertiary Care
Better evidence is needed to determine if a protocol-based treatable trait approach to asthma management is superior to guideline-directed care in those with moderate asthma.
Feasibility and Limitations of Treatable Trait-Based Asthma Management
In conclusion, protocolised treatable trait-based asthma management was acceptable to patients not under the care of a severe asthma clinic, associated with significant clinical benefit, and a full trial appears feasible. Targeting airflow obstruction and type 2 inflammation was insufficient to control asthma in the majority of patients over the timeframe of this study, despite high systemic corticosteroid exposure.
Authors
James Fingleton, Rob McLachlan, Jenny Sparks, Richard Beasley, Alvar Agustí, Peter G. Gibson, Ian D. Pavord, Jo Hardy, Mark Weatherall, Allie Eathorne, Vanessa M. McDonald, the Treatable Traits Study Group
Read more details at
Fecha de publicación
12 March 2025
Categorías asociadas al artículo
Noticias relacionadas
Occluding mucous airway plugs in patients with obstructive lung diseases: a new treatable trait?
Airway mucous plugging is associated with exacerbations, lung function decline, and mortality in COPD, asthma, and bronchiectasis. Identifying it as a treatable trait may improve patient outcomes through airway clearance techniques and pharmacological strategies.
Change is in the air: key questions on the ‘Treatable Traits’ model for chronic airway diseases in primary care
Explore Treatable Traits model for chronic airway diseases like asthma and COPD in primary care. Learn about seven key traits — airflow obstruction, eosinophilic inflammation, adherence, inhaler technique, smoking, low BMI/obesity and anxiety and depression — that guide personalized care.
Aging and Metabolic Changes in COPD Patients
Explore the metabolic changes in COPD patients, highlighting the influence of aging and sex, with pronounced effects in males. Discover how COPD affects protein metabolism and energy production, emphasizing early aging’s impact.
Imagen tomada del artículo y tratada con Canva