Maternal smoking and CC-16: implications for lung development and COPD across the lifespan
Maternal smoking, CC16 and lifelong lung development
Early-life CC16 deficiency and COPD risk
Early-life lung function trajectories predict long-term respiratory health, including COPD risk. Club Cell protein 16 (CC16) is a key determinant of lung health, with low levels associated with impaired lung development, reduced lung function, and COPD.
Cigarette smoking lowers CC16, but it is unknown whether maternal smoking leads to persistent CC16 deficiency from early life, thereby disrupting lung development and predisposing to COPD risk and progression.
Reduced CC16, lung function decline and emphysema progression
Maternal smoking was linked to reduced circulating and airway CC16 in COPD patients, controls, and a preclinical murine COPD model.
In human adults, lower CC16 correlated with accelerated lung function decline and emphysema progression, while in children it was associated with obstructive physiology and early small airway impairment.
Maternal smoking and CC16: implications for COPD outcomes
Maternal smoking reduces CC16 levels, disrupting lung development in ways that predispose to lifelong impairment of lung function and worse COPD outcomes.
Defining the mechanisms by which CC16 regulates lung maturation is essential for establishing reliable outcome measures and designing trials aimed at preventing early COPD.
Authors
Joselyn Rojas-Quintero, Rosa Faner, Chia-Ying Chiu, Jeffrey T Kue, Yan Zhang, David Sanz Rubio, Anna S Colborg, Claudia A Jakwerth, Carsten B Schmidt-Weber, Anke-Hilse Maitland-van der Zee, Mahmoud I Abdel-Aziz, Andrea L Pilon, Caroline A Owen, Elizabeth J Plosa, Gregory L Kinney, Sharon Mc-Grath Morrow, Mariana G Gazzaneo, Nilda Cortes Santiago, Krithika Lingappan, Julie G Ledford, Jason Spence, Jennifer M Sucre, Maor Sauler, Thomas D Wu, Alvar Agusti, Aimee Wheelock, Sabine Illi, Erika von Mutius, Russell P Bowler, Bartolome Celli, Steven H Abman, James M Wells, Francesca Polverino.
Read more details at
Fecha de publicación
Issue 3, March 2026. Published: 07 October 2025
Categorías asociadas al artículo
Noticias relacionadas
COPD Management in Primary Care: Underutilisation of Nursing Consultations
Analysis of COPD management in primary care highlighting the role and underutilisation of nursing consultations and healthcare utilisation patterns in real-world patients.
Exploring the association between eosinophils and autoimmunity in COPD
Study exploring the association between eosinophils and circulating autoantibodies in COPD patients, considering airflow limitation and smoking status.
Predictores de progresión en la pre-EPOC: estudio 3P, justificación y diseño
Conoce el estudio 3P que analiza los factores que predicen la progresión de la pre-EPOC a EPOC en fumadores con espirometría normal.
General population-based lung function trajectories over the life course: an accelerated cohort study
Empirical life course lung function trajectories from ages 4–80 using data from eight cohort studies in Europe and Australia.
Éxito en la segunda edición de RESPrimaria en la UB
La Segunda Edición de RESPrimaria reunió a 350 profesionales en la UB con sesiones clínicas sobre EPOC, IA, nutrición, salud mental y ventilación no invasiva.
Alteraciones espirométricas y sus factores de riesgo en la población joven ambulatoria
Un estudio reciente en Osona (Cataluña) refleja que 20,7% de jóvenes presenta alteraciones espirométricas. También revela síntomas y factores de riesgo en la población joven ambulatoria.
Imagen desarrollada con ChatGPT