Bronchial and Systemic Relationships of Haemophilus in Chronic Obstructive Pulmonary Disease
Haemophilus in COPD: Bronchial Microbiome Assessment
The aim of the study was to assess the microbial composition of bronchial secretions in chronic obstructive pulmonary disease (COPD), focusing on the impact of the exacerbation patterns on the common components of the respiratory flora and their relationship with inflammatory proteins.
Bronchial Microbiome and Exacerbation Patterns
Beta-diversity analyses of the bronchial microbiome showed significant differences between infrequent and frequent (≥2) exacerbators (p = 0.001). Haemophilus was underrepresented in frequent exacerbators (relative abundance [RA] 0.07 [0.003–0.31] vs. 0.24 [0.06–2.36], p = 0.02) while the presence of Pseudomonas was increased (7.70 [0.66–11.68] vs. 1.11 [0.37–2.88], p = 0.01).
Haemophilus and Blood Interleukin-8
The RAs of common bronchial bacteria were closely related and some of them were inversely associated with blood IL-8 levels.
Authors
Monsó E, Casadevall C, Quero S, Pascual S, Enríquez-Rodríguez C, Millares L, Montón C, Faner R, Capilla S, Seijo L, Castro-Acosta A, Alvarez C, Sibila O, Peces-Barba G, Cosio B, Agusti A, Gea J.
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Fecha de publicación
Published – 10 April 2026
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