Telomere length in patients with bronchiectasis
Background: The Role of Telomere Length in Bronchiectasis and Respiratory Diseases
Accelerated ageing markers such as telomere length (TL) have been associated with respiratory diseases such as COPD.
However, its role has not been deeply studied in the chronic lung disease bronchiectasis.
Our aims were: (1) to compare the association of TL with bronchiectasis vs. COPD and controls with normal lung function, and (2) to explore the association of TL with bronchiectasis aetiology and severity.
Methods: Measuring Telomere Length in Bronchiectasis, COPD, and Healthy Controls
Bronchiectasis, COPD patients and healthy volunteers were recruited in 2 tertiary hospitals in Barcelona, Spain.
DNA from whole blood was used to quantify TL by real-time polymerase chain reaction (qPCR). TL results were adjusted by age, gender and smoking status.
Results: Telomere Length Comparison in Bronchiectasis, COPD, and Control Groups
174 stable bronchiectasis patients, 240 COPD patients and 227 healthy donors were analysed.
The mean age of bronchiectasis patients was 69±12 years, 53% were idiopathic and the mean Bronchiectasis Severity Index (BSI) was 6.8±4.3.
The adjusted model showed that bronchiectasis patients have a similar TL to normal lung function controls (p=0.7) and a longer TL than COPD patients (p<0.001).
The bronchiectasis aetiology analysis showed that patients with idiopathic bronchiectasis tend to have a decrease in telomere length (p=0.06), but no differences in disease severity were found.
Conclusions: Understanding Telomere Length in Bronchiectasis Patients and Future Research
Patients with bronchiectasis do not present a decrease in telomere length compared with controls or COPD patients. A trend to decrease TL in patients with idiopathic bronchiectasis was found.
Further studies are needed to clarify the role of TL in the physiopathology of the disease.
Authors
Lídia Perea, Sandra Casas, Estrella Caballeria, Belén Solarat, Tamara Garcia, Núria Mendoza, Pilar Martínez-Olondris, Patricia Chang-Macchiu, Alvar Agustí, Amelia Shoemark, James D Chalmers, Rosa Faner, Oriol Sibila
Read more details at
Fecha de publicación
Published online October 27, 2023.
Categorías asociadas al artículo
Noticias relacionadas
Pathophysiology and genomics of bronchiectasis
Explore the complex pathophysiology of bronchiectasis, including airway infection, chronic inflammation, and mucociliary dysfunction. Learn how genomic approaches, proteomics, and epigenomics offer new insights into disease endotypes and patient stratification for improved therapies. Discover the role of trained innate immunity in complementing current models.
Aspergillus Testing and Disease Outcomes in Bronchiectasis: Data From the EMBARC Registry
Aspergillus-associated disorders in bronchiectasis, based on data from the EMBARC Registry. ABPA, AS, and AB: Impact on disease severity, diagnostic criteria efficacy, etc.
Changes in Blood Immune Cell Transcriptomes Associate With Disease Severity, Infection, and Inflammation in Bronchiectasis Patients
Marked differences in peripheral blood immune cell gene expression were observed between bronchiectasis patients and healthy controls.
Transcriptomic changes were associated with disease severity and airway inflammation identifying potential novel biomarkers and therapeutic targets.
Artículos
Lung function
- 759688· Prof Eric Melen et Al. – Lung-function trajectories: relevance and implementation in clinical practice.
- 769289·Caspar Schiffers, Rosa Faner, et al. Supranormal lung function: Prevalence, associated factors and clinical manifestations across the lifespan.
- 769491·Tamara Cruz, Núria Mendoza, Gema M Lledó, Lídia Perea, Núria Albacar, Alvar Agustí, Jacobo Sellares, Oriol Sibila, Rosa Faner. Persistence of a SARS-CoV-2 T-cell response in patients with long COVID and lung sequelae after COVID-19
- 769799·Alvar Agusti, Peter G. Gibson, Vanessa M. McDonald. Treatable Traits in Airway Disease: From Theory to Practice
- 778797· Xavier Alsina-Restoy, Rodrigo Torres-Castro, Yolanda Torralba García, Felip Burgos, Joan Albert Barberà, Àlvar Agustí, Isabel Blanco Does arterial oxygenation during exercise add prognostic value in pulmonary arterial hypertension?
Imagen desarrollada desde DALL·E, tratamiento gráfico y Canva
