Trajectories of airflow limitation from childhood to early adulthood: an analysis of six population-based birth cohorts
Airflow Limitation and Lung Development from Birth to Early Adulthood
Lungs of full-term, healthy neonates are not yet fully developed at birth, and their growth and development continue until early adulthood, at which point lung function peaks and then steadily declines.
The developing lung is susceptible to adverse environmental exposures, potentially leading to lower maximally attained lung function.
Conversely, during postnatal development, recovery from prenatal and early-life insults can occur.
This ability to repair and rebuild lung structure is a hallmark of lung health. These dynamic processes should be reflected in the catch-up and growth failure or decline in lung function parameters.
Changes in Airflow Limitation Across the Lifespan and Health Interventions
Worsening and improvement in airflow limitation from school age to adulthood might occur at all ages and all airflow obstruction severity levels. Interventions to optimise healthy weight, including tackling overweight and obesity (particularly among children with wheezing) as well as treating underweight among non-wheezers, could help to improve lung health across the lifespan.
Authors
Anhar Ullah, MSc, Raquel Granell, PhD, Lesley Lowe PhD, Sara Fontanella PhD, Prof Hasan Arshad, DM, Clare S Murray, MD, Prof Steve Turner MD, Prof John W Holloway PhD, Prof Angela Simpson PhDd, Prof Graham Roberts DM, Gang Wang, MD, Prof Jadwiga A Wedzicha, MD, Prof Rosa Faner, PhD, Hans Jacob L Koefoed MD, Judith M Vonk PhD, Prof Alvar Agusti, PhD, Prof Gerard H Koppelman PhDn, Prof Erik Melén MD, Prof Adnan Custovic PhD
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Fecha de publicación
March 2025
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