Characterisation of the gut-lung axis microbiome in clinically stable patients with chronic obstructive pulmonary disease
Gut-Lung Axis Microbiome in Clinically Stable COPD
Airway and gut dysbiosis have been reported in Chronic Obstructive Pulmonary Disease (COPD); however, their relationship and association with clinical features remain poorly understood.
We aimed to characterise the lung and gut microbiome in patients with stable COPD and controls.
Airway and Gut Microbiome Findings in COPD
We found that the microbiome in airway and stool samples was highly dissimilar both in patients and controls, with 0.37% of this diversity associated to COPD.
The microbiome taxa associated with COPD in OP swabs and sputum were highly similar, but different from BALF, suggesting that OP swabs can be a surrogate sample of sputum.
Clinical Relevance of the Gut-Lung Axis Microbiome
The gut and lung microbiomes in patients with COPD are distinct, but both clinically relevant as both present bacterial associations with airflow limitation, exacerbation history, and ICS use.
Authors
Julieta Viglino, Lidia Perea, Marian Garcia-Nuñez, Ana Rodrigo-Troyano, Alfons Torrego, Marisol Domínguez-Alvarez, Judith Villar, Xènia Carrizosa, Sara Quero, Toni Gabaldon, Jesse R Willis, Ester Saus, Joaquim Gea, Salud Santos, Paula Camps, Alvar Agustí, Eduard Monso, Oriol Sibila, Rosa Faner.
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Fecha de publicación
Publication date (Epub): 2 January 2026.
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